Identifying the RNA Binding Sites on the MeCP2 Protein by Regional Deletion
DOI:
https://doi.org/10.33011/cuhj20242289Abstract
Long non-coding RNAs (LncRNAs) have been found to bind to the Methyl-CpG binding protein (MeCP2), which has been speculated to play a role in altering chromatin structure and regulating gene expression. Whether MeCP2 has other important functions related to RNA processing, the nature of the LncRNA-MeCP2 interaction and function, and how this may affect brain development is unknown. The goal of my project is to provide insight into important regions or domains of the MeCP2 protein involved in RNA binding. With this new information, a foundation for further in-depth research will be established, on the involvement of the MeCP2 protein in the pathogenesis of Rett Syndrome, through RNA binding and RNA regulation.
For the full text, please visit https://scholar.colorado.edu/concern/undergraduate_honors_theses/mw22v689v.
Downloads
Published
How to Cite
Issue
Section
License
Authors whose work is accepted and who publish with The University of Colorado Honors Journal agree to the following terms:
1. The Author retains copyright in the Work, where the term “Work” shall include all objects that may result in subsequent electronic or print publication or distribution.
2. Upon acceptance of the Work, the author shall grant to the Publisher the right of first publication of the Work.
3. The Author shall grant to the Publisher and its agents the nonexclusive perpetual right and license to publish, archive, and make accessible the Work in whole or in part in all forms of media now or hereafter known under a non-exclusive license, which grants the Journal the right to copy, distribute, and transmit the Work under the following conditions: a. Right of publication in the print format of the journal; b. Right of publication in the online and/or digital format of the journal; c. Right to use in promotional or other journal-related activities, as defined by the journal.
4. Upon Publisher’s request, the Author agrees to furnish promptly to Publisher, at the Author’s own expense, written evidence of the permissions, licenses, and consents for use of third-party material included within the Work, except as determined by Publisher to be covered by the principles of Fair Use.
5. The Author represents and warrants that: a. the Work is the Author’s original work; b. the Author has not transferred, and will not transfer, exclusive rights in the Work to any third party; c. the Work is not pending review or under consideration by another publisher; d. the Work has not previously been published; e. the Work contains no misrepresentation or infringement of the Work or property of other authors or third parties; and f. the Work contains no libel, invasion of privacy, or other unlawful matter.
6. The Author agrees to indemnify and hold Publisher harmless from Author’s breach of the representations and warranties contained above, as well as any claim or proceeding relating to Publisher’s use and publication of any content contained in the Work, including third-party content.
11-August-2014
